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The REBALANCE Study

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 PCOS is caused by a hormone imbalance which can affect the menstrual cycle. The REBALANCE Study is evaluating the safety and effectiveness of an investigational procedure called Ovarian Rebalancing, intended to help women ovulate.  The procedure is a one-time, outpatient procedure performed using pain medication and sedation and should take about one hour. The procedure uses radiofrequency energy to gently heat a small portion of the ovarian tissue responsible for hormone production, which is intended to help with ovulation.   Key entry criteria are women who: Are between 18-40 years old Are experiencing an ovulation infertility due to PCOS Have a BMI <40 Have had no clinical response to ovulation induction treatment such as letrozole or clomiphene citrate or are contraindicated for or decline such treatment Are currently seeking immediate fertility Some participants will be part of a control group who will receive no treatment. Participants who are randomly assigned ...
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Male Factor Infertility

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Male Factor Infertility, which accounts for about 40% of infertility cases, occurs when a man’s sperm production, quality, or ability to reach the egg is impaired, leading to an inability to conceive. Some causes of male infertility are: Sperm Disorders - Low sperm count - Poor sperm quality - Abnormal sperm morphology (sperm with structural defects) - Azoospermia (absence of sperm in the ejaculate) Structural Problems - Varicoceles (Enlarged veins in the scrotum that can raise testicular temperature and impair sperm production) - Blockages in the reproductive tract Hormonal Imbalances - Low testosterone levels - Problems with the hypothalamus or pituitary gland (these glands regulate hormone production) Genetic Factors - Chromosomal abnormalities - Y chromosome micro-deletions - Cystic fibrosis (genetic condition that can cause congenital absence of the vas deferens) Lifestyle and Environmental Factors - Exposure to heat - Drug use - Alcohol consumption - Smoking - Obesity - Exposure ...
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Infertility Overview

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Infertility is defined as the inability to conceive children or young after 12 months or more of regular unprotected sexual intercourse. Approximately 1 in 6 couples trying to conceive experience infertility. Infertility can cause significant distress, stigma, and financial hardship, affecting peoples mental and psychosocial well-being.  Solutions for the prevention, diagnosis and treatment of infertility such as, Intrauterine Insemination (IUI), and In Vitro Fertilization (IVF), remain severely underfunded and inaccessible to many due to high costs and limited availability. Resources https://www.who.int/news/item/04-04-2023-1-in-6-people-globally-affected-by-infertility https://continentalhospitals.com/diseases/female-infertility/ https://www.inovifertility.com/blog/iui-vs-ivf-comparison-considerations/
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